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Terbinafine Lamisil Tablets vs. Sporanox Tablets: Which one?


The only two tablets approved by the FDA for the treatment of fungal infections on the skin and toes are Terbinafine Lamisil Tablets and Sporanox Tablets. Doctor's debate which one to prescribe to patients. As we will see later in this article, both Terbinafine Lamisil Tablets and Sporanox Tablets have advantages and disadvantages when compared to one-another. 

Lamisil TabletsWeather a simple foot spray or Terbinafine Tablets, Lamisil has established its' name worldwide as a leader in anti fungal treatment. One could argue that Lamisil's least successful product in terms of effectiveness in treating fungus is Terbinafine Lamisil Tablets. Clinical trials were conducted and Terbinafine tablets were deemed only 38% successful in clearing toenail fungus. This is fairly low for a treatment that can cost a few hundred dollars a month. 

Sporanox TabletsSporanox Tablets are the other oral prescription anti fungal available today. Itraconazole, the generic name for Sporanox, is used to fight fungal infections of the lungs as well as toenails and skin. When clinically tested for the treatment of Onychomoshosis (Toenail Fungus), Sporanox Tablets recorded a 14% success rate. Dismal; even when compared to the 38% recorded by Terbinafine Lamisil Tablets.

The chart below outlines characteristics about Terbinafine Lamisil Tablets and Sporanox Tablets that should be considered when deciding which one (if any!) to take.

Terbinafine Lamisil Tablets vs. Sporanox Tablets 

Treatment Name 


Terbinafine Lamisil Tablets


Sporanox Tablets

 Over-the-counter, Prescription or Home Remedy




Published Effectiveness

 38% in clinical trials

 14% in clinical trials


 $300-$500 per month

$300-$500 per month


Active Anti-Fungal Ingredient

 Terbinafine Hydrochloride



One 250 mg tablet once daily for 12 weeks

 Recommended: 200 mg (2 capsules) once daily for 12 consecutive weeks. Can increase dose by 100 mg increments - 400 mg max

 Side Effects

Public Health Advisory Issued 

Side effects include:

Liver Damage/ Failiure, 

Cardiac Risks,


Stomach Ache,



Altered taste sensation

Public Health Advisory Issued 

Side effects include:

Liver Damage/ failure, 

Cardiac Risks,

Diarrhea/ Gas,

Stomach Ache,


Blocked Sinus,

Headache/ Dizziness

 Nail Polish Safe




Money Back Guarantee

 No, there is actually a high rate of recurrence within one year.  

 No, there is actually a high rate of recurrence within one year.  


 Sold Through 

Doctor prescribed 

 Doctor prescribed


After reviewing the table it is obvious that there are a couple common disadvantages between Terbinafine Lamisil Tablets and Sporanox Tablets. First, the laundry list of side effects that accompany the treatments is astronomical. Additionally, it is required that patients do not drink or smoke when prescribed anti fungal tablets. Finally, the cost of both treatments is to high to have to pay out of pocket. 

The other major treatments available for toenail fungus are Anti-Fungal Nail Lacquers and Anti-fungal Lasers. In the past Nail Lacquers have not been very effective, but there are new products emerging that have proven to be more successful. Anti-fungal Lasers are relatively new and only a handful have been FDA approved. It is becoming common practice to combine Laser treatment with a Lacquer but Laser Treatment cost about $1000 and is not covered by insurance. 

Many doctors fray away from prescribing anti-fungal tablets for the treatment of toenail fungus because of the side effects and the high potential of the fungus returning. 



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